Clinical Research Core

The Transplant Clinical Research Core coordinates clinical trials, giving UVa Transplant patients access to the most up-to-date treatment options. Our clinical trials evaluate investigational new drugs and best practices in liver, kidney, and islet cell transplantation.

Below we have listed trials open to enrollment and current clinical trials. Each trial has a Primary Clinical Research Coordinator. Their contact information is also listed. Please get in touch with them if you have questions about the trials.

For any other enquiries about the Clinical Research Core, please contact Clinical Research Coordinator Andrea Ruhsam at alr8q@virginia.edu.

Trials Open to Enrollment

IRB-HSR# 17340
A 24 month, multicenter, randomized, open-label safety and efficacy study of concentration-controlled everolimus with reduced calcineurin inhibitor vs mycophenolate with standard calcineurin inhibitor in de novo renal transplantation- Advancing renal transplant efficacy and safety outcomes with an everolimus based regimen (TRANSFORM)
Principal Investigator: Kenneth Brayman, MD, PhD
Primary Clinical Research Coordinator: Andrea Ruhsam, 434-243-6156, ALR8Q@virginia.edu
National Clinical Trial #: NCT01950819

IRB-HSR# 17287
A 24 month, randomized, controlled, study to evaluate the efficacy and safety of concentration-controlled everolimus plus reduced tacrolimus compared to standard tacrolimus in recipients of living donor liver transplants
Principal Investigator: Daniel Maluf, MD
Interim Clinical Research Coordinator: Andrea Ruhsam, 434-243-6156, ALR8Q@virginia.edu
National Clinical Trial #: NCT01888432

IRB-HSR# 16895
Evaluation of the Benefits and Risks in Maintenance Renal Transplant Recipients Following Conversion to Nulojix® (belatacept)-based Immunosuppression
Principal Investigator: Avinash Agarwal, MD
Primary Clinical Research Coordinator: Buki Akinola, RN, 434-982-3665, AA5RH@virginia.edu
National Clinical Trial #: NCT01820572

IRB-HSR# 16803
A Multi-Center, Randomized, Prospective, Open-Label III Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Hepatitis C Immune Globulin (HCIG) in Orthotopic Liver Transplant Recipients
Principal Investigator: Daniel Maluf, MD
Interim Clinical Research Coordinator: Andrea Ruhsam, 434-243-6156, ALR8Q@virginia.edu
National Clinical Trial #: NCT01804829

IRB-HSR# 16091
Evaluating Nulojix Long Term Safety In Transplant ENLIST Registry
Principal Investigator: Avinash Agarwal, MD
Primary Clinical Research Coordinator: Buki Akinola, RN, 434-982-3665, AA5RH@virginia.edu
National Clinical Trial #: NCT01386359

IRB-HSR# 16835
A Prospective, Single-blind, Randomized, Phase III Study to Evaluate the Safety and Efficacy of Fibrin Sealant Grifols (FS Grifols) as an Adjunct to Hemostasis During Parenchymous Tissue Open Surgeries
Principal Investigator: Kenneth Brayman, MD, PhD
Primary Clinical Research Coordinator: Andrea Ruhsam, 434-243-6156, ALR8Q@virginia.edu
National Clinical Trial #: NCT01754480

IRB-HSR# 17454
A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial to Evaluate the Efficacy and Safety of a Vaccine, ASP0113, in Cytomegalovirus (CMV)-Seronegative Kidney Transplant Recipients Receiving an Organ from a CMV-Seropositive Donor
Principal Investigator: Kenneth Brayman, MD, PhD
Interim Clinical Research Coordinator: Andrea Ruhsam, 434-243-6156, ALR8Q@virginia.edu
National Clinical Trial #: NCT01974206

IRB-HSR# 17491
A Randomized Parallel-Group, Double blind, Placebo Controlled, Multi-Center Study of Eculizumab for the prevention of delayed graft function after kidney transplantation in adult subjects at increased risk of delayed graft function
Principal Investigator: Kenneth Brayman, MD, PhD
Primary Clinical Research Coordinator: Buki Akinola, RN, 434-982-3665, AA5RH@virginia.edu
National Clinical Trial #: NCT02145182

Future Trials

IRB-HSR# 17842
Evaluation of Acute Rejection Rates in de novo Renal Transplant Recipients Following Thymoglobulin Induction, CNI-free, Nulojix (belatacept)-based Immunosuppression
Principal Investigator: Avinash Agarwal, MD
Primary Clinical Research Coordinator: Andrea Ruhsam, 434-243-6156, ALR8Q@virginia.edu
National Clinical Trial #: NCT02137239

IRB # Not Assigned Yet
Multicenter Pilot Study of BB3 to Improve Renal Function in Patients with Signs and Symptoms of Significant Renal Injury after Kidney Transplantation and at Risk for Dialysis
Principal Investigator: Kenneth Brayman, MD, PhD
Primary Clinical Research Coordinator: Andrea Ruhsam, 434-243-6156, ALR8Q@virginia.edu
National Clinical Trial #: NCT01286727