- Professor of Biomedical Engineering
- Professor of Opthamology
- Professor of Plastic Surgery
Department of Biomedical Engineering University of Virginia Box 800759, Health System Charlottesville, VA 22908
415 Lane Road, Room 2041
Charlottesville, VA 22903
About Shayn Peirce-Cottler
Dr. Peirce-Cottler’s laboratory develops technologies for regenerating tissues and therapies for ameliorating disease (such as diabetes and cardiovascular disease) by targeting the microvasculature — the smallest blood vessels in the body, which are responsible for delivering oxygen and nutrients to all tissues and organs. Dr. Peirce-Cottler uses a combination of adult stem cells and pharmacological interventions to control the growth and function of small blood vessels in the body and in 3D-printed bioimplants. She also researches how acute and chronic inflammation affect microvessel growth and tissue regeneration in wound healing and autoimmune diseases. In addition to evaluating technologies in pre-clinical disease models, Dr. Perice-Cottler also uses computational modeling to inform her laboratory’s studies and to design new therapeutic approaches.
When she is not working, Dr. Peirce-Cottler enjoys playing with Legos with her two sons and playing golf with her husband.
Microvascular Growth and Remodeling, Tissue Engineering and Regeneration, Diabetic Retinopathy, Computational Systems Biology
- Postdoctoral Fellowship, Biomedical Engineering, University of Virginia
- Ph.D., Biomedical Engineering, University of Virginia
- B.S., Biomedical Engineering, The Johns Hopkins University
Martin KS, Blemker SS, Peirce SM, Agent-based computational model investigates muscle-specific responses to disuse-induced atrophy. 2015; 1299-309; Journal of applied physiology (Bethesda, Md. : 1985). PMID: 25722379Cronk SM, Kelly-Goss MR, Ray HC, Mendel TA, Hoehn KL, Bruce AC, Dey BK, Guendel AM, Tavakol DN, Herman IM, Peirce SM, Yates PA, Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy. 2015; 459-67; Stem cells translational medicine. PMID: 25769654 Heuslein JL, Li X, Murrell KP, Annex BH, Peirce SM, Price RJ, Computational Network Model Prediction of Hemodynamic Alterations Due to Arteriolar Rarefaction and Estimation of Skeletal Muscle Perfusion in Peripheral Arterial Disease. 2015; ; Microcirculation (New York, N.Y. : 1994). PMID: 25866235 Virgilio KM, Martin KS, Peirce SM, Blemker SS, Multiscale models of skeletal muscle reveal the complex effects of muscular dystrophy on tissue mechanics and damage susceptibility. 2015; 20140080; Interface focus. PMID: 25844152 Murfee WL, Sweat RS, Tsubota K, Mac Gabhann F, Khismatullin D, Peirce SM, Applications of computational models to better understand microvascular remodelling: a focus on biomechanical integration across scales. 2015; 20140077; Interface focus. PMID: 25844149 Agrawal H, Shang H, Sattah AP, Yang N, Peirce SM, Katz AJ, Human adipose-derived stromal/stem cells demonstrate short-lived persistence after implantation in both an immunocompetent and an immunocompromised murine model. 2014; 142; Stem cell research & therapy. PMID: 25523792 Bruce AC, Kelly-Goss MR, Heuslein JL, Meisner JK, Price RJ, Peirce SM, Monocytes are recruited from venules during arteriogenesis in the murine spinotrapezius ligation model. 2014; 2012-22; Arteriosclerosis, thrombosis, and vascular biology. PMID: 24969773 Kelly-Goss MR, Sweat RS, Stapor PC, Peirce SM, Murfee WL, Targeting pericytes for angiogenic therapies. 2014; 345-57; Microcirculation (New York, N.Y. : 1994). PMID: 24267154 Mendel TA, Clabough EB, Kao DS, Demidova-Rice TN, Durham JT, Zotter BC, Seaman SA, Cronk SM, Rakoczy EP, Katz AJ, Herman IM, Peirce SM, Yates PA, Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy. 2013; e65691; PloS one. PMID: 23741506 Guendel AM, Martin KS, Cutts J, Foley PL, Bailey AM, Mac Gabhann F, Cardinal TR, Peirce SM, Murine spinotrapezius model to assess the impact of arteriolar ligation on microvascular function and remodeling. 2013; e50218; Journal of visualized experiments : JoVE. PMID: 23486360 Walpole J, Papin JA, Peirce SM, Multiscale computational models of complex biological systems. 2013; 137-54; Annual review of biomedical engineering. PMID: 23642247 Taylor AC, Mendel TA, Mason KE, Degen KE, Yates PA, Peirce SM, Attenuation of ephrinB2 reverse signaling decreases vascularized area and preretinal vascular tuft formation in the murine model of oxygen-induced retinopathy. 2012; 5462-70; Investigative ophthalmology & visual science. PMID: 22789927 Yang M, Stapor PC, Peirce SM, Betancourt AM, Murfee WL, Rat mesentery exteriorization: a model for investigating the cellular dynamics involved in angiogenesis. 2012; e3954; Journal of visualized experiments : JoVE. PMID: 22643964 Peirce SM, Mac Gabhann F, Bautch VL, Integration of experimental and computational approaches to sprouting angiogenesis. 2012; 184-91; Current opinion in hematology. PMID: 22406822 Bruce AC, Peirce SM, Exogenous thrombin delivery promotes collateral capillary arterialization and tissue reperfusion in the murine spinotrapezius muscle ischemia model. 2012; 143-54; Microcirculation (New York, N.Y. : 1994). PMID: 21954923 Amos PJ, Mulvey CL, Seaman SA, Walpole J, Degen KE, Shang H, Katz AJ, Peirce SM, Hypoxic culture and in vivo inflammatory environments affect the assumption of pericyte characteristics by human adipose and bone marrow progenitor cells. 2011; C1378-88; American journal of physiology. Cell physiology. PMID: 21865587 Hayenga HN, Thorne BC, Peirce SM, Humphrey JD, Ensuring congruency in multiscale modeling: towards linking agent based and continuum biomechanical models of arterial adaptation. 2011; 2669-82; Annals of biomedical engineering. PMID: 21809144 Billaud M, Ross JA, Greyson MA, Bruce AC, Seaman SA, Heberlein KR, Han J, Best AK, Peirce SM, Isakson BE, A new method for in vivo visualization of vessel remodeling using a near-infrared dye. 2011; 163-71; Microcirculation (New York, N.Y. : 1994). PMID: 21418375 Sefcik LS, Aronin CE, Awojoodu AO, Shin SJ, Mac Gabhann F, MacDonald TL, Wamhoff BR, Lynch KR, Peirce SM, Botchwey EA, Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth. 2011; 617-29; Tissue engineering. Part A. PMID: 20874260 Benedict KF, Mac Gabhann F, Amanfu RK, Chavali AK, Gianchandani EP, Glaw LS, Oberhardt MA, Thorne BC, Yang JH, Papin JA, Peirce SM, Saucerman JJ, Skalak TC, Systems analysis of small signaling modules relevant to eight human diseases. 2011; 621-35; Annals of biomedical engineering. PMID: 21132372 Hashambhoy YL, Chappell JC, Peirce SM, Bautch VL, Mac Gabhann F, Computational modeling of interacting VEGF and soluble VEGF receptor concentration gradients. 2011; 62; Frontiers in physiology. PMID: 22007175 Thorne BC, Hayenga HN, Humphrey JD, Peirce SM, Toward a multi-scale computational model of arterial adaptation in hypertension: verification of a multi-cell agent based model. 2011; 20; Frontiers in physiology. PMID: 21720536 Seaman ME, Peirce SM, Kelly K, Rapid analysis of vessel elements (RAVE): a tool for studying physiologic, pathologic and tumor angiogenesis. 2011; e20807; PloS one. PMID: 21694777 Glaw JT, Skalak TC, Peirce SM, Inhibition of canonical Wnt signaling increases microvascular hemorrhaging and venular remodeling in adult rats. 2010; 348-57; Microcirculation (New York, N.Y. : 1994). PMID: 20618692 Mac Gabhann F, Peirce SM, Collateral capillary arterialization following arteriolar ligation in murine skeletal muscle. 2010; 333-47; Microcirculation (New York, N.Y. : 1994). PMID: 20618691 Petrie Aronin CE, Sefcik LS, Tholpady SS, Tholpady A, Sadik KW, Macdonald TL, Peirce SM, Wamhoff BR, Lynch KR, Ogle RC, Botchwey EA, FTY720 promotes local microvascular network formation and regeneration of cranial bone defects. 2010; 1801-9; Tissue engineering. Part A. PMID: 20038198 Amos PJ, Kapur SK, Stapor PC, Shang H, Bekiranov S, Khurgel M, Rodeheaver GT, Peirce SM, Katz AJ, Human adipose-derived stromal cells accelerate diabetic wound healing: impact of cell formulation and delivery. 2010; 1595-606; Tissue engineering. Part A. PMID: 20038211 Taylor AC, Seltz LM, Yates PA, Peirce SM, Chronic whole-body hypoxia induces intussusceptive angiogenesis and microvascular remodeling in the mouse retina. 2010; 93-101; Microvascular research. PMID: 20080108 Volsky PG, Hughley BB, Peirce SM, Kesser BW, Construct validity of a simulator for myringotomy with ventilation tube insertion. 2009; 603-608.e1; Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. PMID: 19861198 Bailey AM, Lawrence MB, Shang H, Katz AJ, Peirce SM, Agent-based model of therapeutic adipose-derived stromal cell trafficking during ischemia predicts ability to roll on P-selectin. 2009; e1000294; PLoS computational biology. PMID: 19247427 Chavali AK, Gianchandani EP, Tung KS, Lawrence MB, Peirce SM, Papin JA, Characterizing emergent properties of immunological systems with multi-cellular rule-based computational modeling. 2008; 589-99; Trends in immunology. PMID: 18964301 Peirce SM, Computational and mathematical modeling of angiogenesis. 2008; 739-51; Microcirculation (New York, N.Y. : 1994). PMID: 18720228 Amos PJ, Shang H, Bailey AM, Taylor A, Katz AJ, Peirce SM, IFATS collection: The role of human adipose-derived stromal cells in inflammatory microvascular remodeling and evidence of a perivascular phenotype. 2008; 2682-90; Stem cells (Dayton, Ohio). PMID: 18436860 Bailey AM, O'Neill TJ, Morris CE, Peirce SM, Arteriolar remodeling following ischemic injury extends from capillary to large arteriole in the microcirculation. 2008; 389-404; Microcirculation (New York, N.Y. : 1994). PMID: 18574742 Birchenough SA, Rodeheaver GT, Morgan RF, Peirce SM, Katz AJ, Topical poloxamer-188 improves blood flow following thermal injury in rat mesenteric microvasculature. 2008; 584-8; Annals of plastic surgery. PMID: 18434836 Amos PJ, Bailey AM, Shang H, Katz AJ, Lawrence MB, Peirce SM, Functional binding of human adipose-derived stromal cells: effects of extraction method and hypoxia pretreatment. 2008; 437-44; Annals of plastic surgery. PMID: 18362576 Thorne BC, Bailey AM, DeSimone DW, Peirce SM, Agent-based modeling of multicell morphogenic processes during development. 2007; 344-53; Birth defects research. Part C, Embryo today : reviews. PMID: 18228259 Robertson SH, Smith CK, Langhans AL, McLinden SE, Oberhardt MA, Jakab KR, Dzamba B, DeSimone DW, Papin JA, Peirce SM, Multiscale computational analysis of Xenopus laevis morphogenesis reveals key insights of systems-level behavior. 2007; 46; BMC systems biology. PMID: 17953751 Thorne BC, Bailey AM, Peirce SM, Combining experiments with multi-cell agent-based modeling to study biological tissue patterning. 2007; 245-57; Briefings in bioinformatics. PMID: 17584763 Bailey AM, Thorne BC, Peirce SM, Multi-cell agent-based simulation of the microvasculature to study the dynamics of circulating inflammatory cell trafficking. 2007; 916-36; Annals of biomedical engineering. PMID: 17436112 Taylor AC, Murfee WL, Peirce SM, EphB4 expression along adult rat microvascular networks: EphB4 is more than a venous specific marker. ; 253-67; Microcirculation (New York, N.Y. : 1994). PMID: 17454677 Murfee WL, Rehorn MR, Peirce SM, Skalak TC, Perivascular cells along venules upregulate NG2 expression during microvascular remodeling. ; 261-73; Microcirculation (New York, N.Y. : 1994). PMID: 16627368 Murfee WL, Skalak TC, Peirce SM, Differential arterial/venous expression of NG2 proteoglycan in perivascular cells along microvessels: identifying a venule-specific phenotype. 2005; 151-60; Microcirculation (New York, N.Y. : 1994). PMID: 15824037 Longo D, Peirce SM, Skalak TC, Davidson L, Marsden M, Dzamba B, DeSimone DW, Multicellular computer simulation of morphogenesis: blastocoel roof thinning and matrix assembly in Xenopus laevis. 2004; 210-22; Developmental biology. PMID: 15196962 Peirce SM, Van Gieson EJ, Skalak TC, Multicellular simulation predicts microvascular patterning and in silico tissue assembly. 2004; 731-3; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. PMID: 14766791 Peirce SM, Price RJ, Skalak TC, Spatial and temporal control of angiogenesis and arterialization using focal applications of VEGF164 and Ang-1. 2004; H918-25; American journal of physiology. Heart and circulatory physiology. PMID: 14604856 Peirce SM, Skalak TC, Microvascular remodeling: a complex continuum spanning angiogenesis to arteriogenesis. 2003; 99-111; Microcirculation (New York, N.Y. : 1994). PMID: 12610666 Hirschi KK, Skalak TC, Peirce SM, Little CD, Vascular assembly in natural and engineered tissues. 2002; 223-42; Annals of the New York Academy of Sciences. PMID: 12081906 Peirce SM, Skalak TC, Rieger JM, Macdonald TL, Linden J, Selective A(2A) adenosine receptor activation reduces skin pressure ulcer formation and inflammation. 2001; H67-74; American journal of physiology. Heart and circulatory physiology. PMID: 11406470 Peirce SM, Skalak TC, Rodeheaver GT, Ischemia-reperfusion injury in chronic pressure ulcer formation: a skin model in the rat. ; 68-76; Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. PMID: 10760216