- Research Scientist, Translational Genomics Transplant Core
Office: (434) 243-1134
Fax: (434) 924-5539
University of Virginia
PO Box 800709
Charlottesville, VA 22908
409 Lane Road
Medical Research Building 4 (MR4), Room 1035
Charlottesville, VA, 22908
About Ricardo Gehrau
Dr. Gehrau’s research is being applied for better results in liver, kidney, and pancreas transplants, and in the treatment of Type 1 diabetes, hepatocellular carcinoma, and hepatits C. He is part of the Translational Genomics Transplant Core. Dr. Gehrau aims to identify biomarkers that will help assess the viability of donor organs for transplants and the likelihood that a transplant will be successful, as well as biomarkers to predict the development of type 1 diabetes. He is also working to determine molecular targets for ischemia-reperfusion injury treatment.
Dr. Gehrau’s research projects include the characterization of the structure and transcriptional regulatory mechanisms involved in the KLF6 gene expression and its relationship with specific disease severity including broad types of cancers; identification and validation of a panel of biomarkers using gene expression microarrays with clinical utility for Hepatocellular Carcinoma (HCC) surveillance testing HCV-cirrhotic non-tumor tissue; molecular characterization of ischemia/reperfusion injury by data integration analysis from gene expression and microRNA profiles; the identification of gene expression profiles to differentiate ACR from HCV recurrence and a microRNA profile to predict severe HCV recurrence disease; molecular mechanisms involved in the B1-lymphocytes proliferation; transcriptional regulation of the BCL-6 and Galectin-3 genes; and microRNA expression profiling assays in pancreatic tissue and peripheral blood mononuclear cells from non-obese diabetic mice undergoing immunoglobulin M therapy.
When he is not working, Dr. Gehrau enjoys spending time with family and friends.
Liver Transplantation, Ischemia/Reperfusion Injury, Biomarkers, IgM Therapy, Hepatitis C Recurrence, Hepatocellular Carcinoma
- Postdoctoral Fellow, Molecular Immunology, National University of Cordoba
- Ph.D., Chemistry and Molecular Biology, National University of Cordoba
- M.S., Biochemistry, National University of Cordoba
Gallon L, Traitanon O, Sustento-Reodica N, Leventhal J, Ansari MJ, Gehrau RC, Ariyamuthu V, De Serres SA, Alvarado A, Chhabra D, Mathew JM, Najafian N, Mas V, Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus. 2014; ; Kidney international. PMID: 25354238Gehrau RC, Mas VR, Suh JL, Maluf DG, Liver transplant complications in hepatitis C infected recipients: recurrence versus rejection. 2014; 453-6; Expert review of gastroenterology & hepatology. PMID: 24641719 Maluf DG, Dumur CI, Suh JL, Scian MJ, King AL, Cathro H, Lee JK, Gehrau RC, Brayman KL, Gallon L, Mas VR, The urine microRNA profile may help monitor post-transplant renal graft function. 2014; 439-49; Kidney international. PMID: 24025639 Gehrau RC, Mas VR, Dumur CI, Ladie DE, Suh JL, Luebbert S, Maluf DG, Regulation of molecular pathways in ischemia-reperfusion injury after liver transplantation. 2013; 926-34; Transplantation. PMID: 23985720 Gehrau RC, Mas VR, Villamil FG, Dumur CI, Mehta NK, Suh JL, Maluf DG, MicroRNA signature at the time of clinical HCV recurrence associates with aggressive fibrosis progression post-liver transplantation. 2013; 729-37; American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID: 23312020 Gehrau RC, Mas VR, Maluf DG, Hepatic disease biomarkers and liver transplantation: what is the potential utility of microRNAs? 2013; 157-70; Expert review of gastroenterology & hepatology. PMID: 23363264 Mas VR, Dumur CI, Scian MJ, Gehrau RC, Maluf DG, MicroRNAs as biomarkers in solid organ transplantation. 2013; 11-9; American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID: 23136949 Gehrau R, Mas V, Archer K, Maluf D, Biomarkers of disease differentiation: HCV recurrence versus acute cellular rejection. 2012; S11; Fibrogenesis & tissue repair. PMID: 23259646 Gehrau RC, Archer KJ, Mas VR, Maluf DG, Molecular profiles of HCV cirrhotic tissues derived in a panel of markers with clinical utility for hepatocellular carcinoma surveillance. 2012; e40275; PloS one. PMID: 22792259 Mas V, Maluf D, Archer KJ, Potter A, Suh J, Gehrau R, Descalzi V, Villamil F, Transcriptome at the time of hepatitis C virus recurrence may predict the severity of fibrosis progression after liver transplantation. 2011; 824-35; Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. PMID: 21618696 Gehrau RC, D'Astolfo DS, Andreoli V, Bocco JL, Koritschoner NP, Differential expression of the klf6 tumor suppressor gene upon cell damaging treatments in cancer cells. 2011; 15-23; Mutation research. PMID: 21147133 Gehrau R, Maluf D, Archer K, Stravitz R, Suh J, Le N, Mas V, Molecular pathways differentiate hepatitis C virus (HCV) recurrence from acute cellular rejection in HCV liver recipients. 2011; 824-33; Molecular medicine (Cambridge, Mass.). PMID: 21519635 Andreoli V, Gehrau RC, Bocco JL, Biology of Krüppel-like factor 6 transcriptional regulator in cell life and death. 2010; 896-905; IUBMB life. PMID: 21154818 Bermejo DA, Amezcua-Vesely MC, Montes CL, Merino MC, Gehrau RC, Cejas H, Acosta-Rodríguez EV, Gruppi A, BAFF mediates splenic B cell response and antibody production in experimental Chagas disease. 2010; e679; PLoS neglected tropical diseases. PMID: 20454564 Gehrau RC, D'Astolfo DS, Dumur CI, Bocco JL, Koritschoner NP, Nuclear expression of KLF6 tumor suppressor factor is highly associated with overexpression of ERBB2 oncoprotein in ductal breast carcinomas. 2010; e8929; PloS one. PMID: 20126619 D'Astolfo DS, Gehrau RC, Bocco JL, Koritschoner NP, Silencing of the transcription factor KLF6 by siRNA leads to cell cycle arrest and sensitizes cells to apoptosis induced by DNA damage. 2008; 613-6; Cell death and differentiation. PMID: 18188167 Gehrau RC, D'Astolfo DS, Prieto C, Bocco JL, Koritschoner NP, Genomic organization and functional analysis of the gene encoding the Krüppel-like transcription factor KLF6. 2005; 137-46; Biochimica et biophysica acta. PMID: 16054710 Gilardoni MB, Ceschin DG, Sahores MM, Oviedo M, Gehrau RC, Chiabrando GA, Decreased expression of the low-density lipoprotein receptor-related protein-1 (LRP-1) in rats with prostate cancer. 2003; 1575-80; The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. PMID: 14623925