- Research Scientist, Cellular Therapy & Transplant Core
Office: (434) 243-0364
Fax: (434) 243-0301
University of Virginia
PO Box 801413
Charlottesville, VA 22908
450 Ray C. Hunt Drive
Fontaine Research Park
Aurbach Building, Room 2335
University of Virginia
Charlottesville, VA 22903
About Preeti Chhabra
A researcher in the Cellular Therapy & Transplant Core, Dr. Chhabra researches type 1 diabetes and transplant immunology. Her preclinical research focuses on strategies to improve islet transplantation outcomes and prevent/reverse the onset, progression and recurrence of type 1 diabetes to permanently restore glycometabolic control.
Dr. Chhabra has examined the role of adenosine A2A receptor agonists as an anti-inflammatory agent to enhance islet transplant outcomes. Her main objective in doing so is to establish the utility of specific and selective A2AR-agonists in reducing the deleterious effects of inflammation that result in islet injury and loss immediately following human islet transplantation. To that end, Dr. Chhabra is working on designing an effective short-term therapeutic strategy using A2AR agonists applied in conjunction with islet transplantation, which would eliminate the need for chronic immunosuppressive therapy, enhance graft survival, and permit the use of minimal number of islets. These studies will also provide a rationale for the use of A2AR agonists and other compounds in the treatment of inflammatory diseases like vascular inflammation, arthritis and asthma, as well as inflammatory disorders associated with ischemia, infection and autoimmunity.
Dr. Chhabra is currently researching the role of mouse and human naturally-occurring immunoglobulin M autoantibodies in preventing or reversing the onset and progression of autoimmune diabetes and establishing permanent tolerance. She has participated in islet isolation in the Cell Processing Core and is trained in data collection for approval for investigational new drugs.
When she is not working, Dr. Chhabra enjoys spending time with family and friends, cooking, reading, writing, travelling, gardening and swimming.
Type 1 Diabetes, Islet Transplantation, Inflammatory Diseases, Transplant Immunosuppression, Tolerance Induction, Regenerative Medicine and Immunoglobulin M Therapy
- Postdoctoral fellowship, Developmental Biology, Indian Institute of Science, Bangalore, India
- Ph.D., Biochemistry/Biology, University of Mysore, India
- M.S., Biochemistry/Biology, University of Mysore, India
- B.S., Biochemistry/Biology, University of Mysore, India
Chhabra P, Brayman KL, Overcoming barriers in clinical islet transplantation: current limitations and future prospects. 2014; 49-86; Current problems in surgery. PMID: 24411187Ramesh A, Chhabra P, Brayman KL, Pancreatic islet transplantation in type 1 diabetes mellitus: an update on recent developments. 2013; 294-311; Current diabetes reviews. PMID: 23721158 Chhabra P, Brayman KL, Stem cell therapy to cure type 1 diabetes: from hype to hope. 2013; 328-36; Stem cells translational medicine. PMID: 23572052 Chhabra P, Linden J, Lobo P, Okusa MD, Brayman KL, The immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation. 2012; 419-33; Current diabetes reviews. PMID: 22934547 Chhabra P, Schlegel K, Okusa MD, Lobo PI, Brayman KL, Naturally occurring immunoglobulin M (nIgM) autoantibodies prevent autoimmune diabetes and mitigate inflammation after transplantation. 2012; 634-41; Annals of surgery. PMID: 22964733 Bowers DT, Chhabra P, Langman L, Botchwey EA, Brayman KL, FTY720-loaded poly(DL-lactide-co-glycolide) electrospun scaffold significantly increases microvessel density over 7 days in streptozotocin-induced diabetic C57b16/J mice: preliminary results. 2011; 3285-7; Transplantation proceedings. PMID: 22099778 Chhabra P, Brayman KL, Current status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation. 2011; 637692; Journal of transplantation. PMID: 22046502 Chhabra P, Wang K, Zeng Q, Jecmenica M, Langman L, Linden J, Ketchum RJ, Brayman KL, Adenosine A(2A) agonist administration improves islet transplant outcome: Evidence for the role of innate immunity in islet graft rejection. 2010; 597-612; Cell transplantation. PMID: 20350347 Chhabra P, Brayman KL, The use of stem cells in kidney disease. 2009; 72-8; Current opinion in organ transplantation. PMID: 19337150 Chhabra P, Mirmira RG, Brayman KL, Regenerative medicine and tissue engineering: contribution of stem cells in organ transplantation. 2009; 46-50; Current opinion in organ transplantation. PMID: 19337146 Palmer LA, Doctor A, Chhabra P, Sheram ML, Laubach VE, Karlinsey MZ, Forbes MS, Macdonald T, Gaston B, S-nitrosothiols signal hypoxia-mimetic vascular pathology. 2007; 2592-601; The Journal of clinical investigation. PMID: 17786245 Baskar R, Chhabra P, Mascarenhas P, Nanjundiah V, A cell type-specific effect of calcium on pattern formation and differentiation in dictyostelium discoideum. 2000; 491-8; The International journal of developmental biology. PMID: 11032184