- Assistant Professor of Surgery
Research Scientist, Cellular Therapy & Transplant Core
Director & Lead Research Scientist, Induced Pluripotent Stem Cell Core
Office: (434) 243-5452
Fax: Fax number: (434) 243-0301
PO Box 801413
University of Virginia
Charlottesville, VA 22908
450 Ray C. Hunt Drive
Aurbach Building, Room 2309
Charlottesville, VA 22903
About Araz Toumadje
Dr. Toumadje is developing a Human-Induced Pluripotent Stem Cell Core, which will enable Transplant to use a patient’s own tissues to create healthy cells that can help the patient overcome disease. Development of the iPSC Core is urgent, as in vitro technologies are badly needed for larger-scale generation of healthy, insulin-producing beta cells to compensate for the shortage of pancreas donors. In the iPSC Core, Dr. Toumadje is currently researching the generation of beta cells from human adipose-derived pluripotent stem cells and derivation of iPSC from islet and acinar cells. He is also part of the Cellular Therapy and Transplant Core.
Dr. Toumadje’s past research includes differentiation of human embryonic stem cells to alveolar type II lung cells, neural stem cells, and dopaminergic neurons. He has developed a new culture system for pluripotent stem cells; a novel in vitro model to study human embryotoxicity; a bead-based flow cytometric assay for telomerase enzyme; and circular dichroism spectroscopy.
Dr. Toumadje has experience both in research laboratories and in industry. He has won two Small Business Innovative Research Awards and a Corporate Product & Technology Development Award. His business experience aids him in translating research success into accessible real-world results.
When he is not working, Dr. Toumadje enjoys watching old movies, spending time with his family, and playing with his grandchildren.
Human Embryonic & Induced Pluripotent Stem Cells Technology, In Vitro Differentiation of Stem Cells to Pancreatic Endocrine Cells such as Insulin-Producing Beta Cells, Flow Cytometry, Telomerase Assay Techniques, Circular Dichroism Spectroscopy, Transplantation, Immunoglobulin M Therapy, Regenerative Medicine
- Postdoctoral Fellow, Biochemistry/Biophysics/Cell Biology, Oregon State University
- Ph.D., Fruit Biochemistry/Physiology of fruit ripening, Oregon State University
- M.S., Plant Biochemistry/Physiology, University of California, Davis
- B.S., Entomology, Pahlavi University, Shiraz, Iran
Josephson R, Ording CJ, Liu Y, Shin S, Lakshmipathy U, Toumadje A, Love B, Chesnut JD, Andrews PW, Rao MS, Auerbach JM, Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research. 2007; 437-46; Stem cells (Dayton, Ohio). PMID: 17284651Plaia TW, Josephson R, Liu Y, Zeng X, Ording C, Toumadje A, Brimble SN, Sherrer ES, Uhl EW, Freed WJ, Schulz TC, Maitra A, Rao MS, Auerbach JM, Characterization of a new NIH-registered variant human embryonic stem cell line, BG01V: a tool for human embryonic stem cell research. 2006; 531-46; Stem cells (Dayton, Ohio). PMID: 16293579 Toumadje A, Kusumoto K, Parton A, Mericko P, Dowell L, Ma G, Chen L, Barnes DW, Sato JD, Pluripotent differentiation in vitro of murine ES-D3 embryonic stem cells. ; 449-53; In vitro cellular & developmental biology. Animal. PMID: 14705957 Buck C, Walsh C, Davis R, Toumadje A, Kusamoto K, Helmrich A, Chapline C, Mericko P, Barnes D, Cell cultures and retroviral particles from a tumor of a moray eel. 2001; S196-202; Marine biotechnology (New York, N.Y.). PMID: 14961316 Bloemendal M, Toumadje A, Johnson WC, Bovine lens crystallins do contain helical structure: a circular dichroism study. 1999; 234-8; Biochimica et biophysica acta. PMID: 10407145 Ivanchenko MG, Lerner JP, McCormick RS, Toumadje A, Allen B, Fischer K, Hedstrom O, Helmrich A, Barnes DW, Bayne CJ, Continuous in vitro propagation and differentiation of cultures of the intramolluscan stages of the human parasite Schistosoma mansoni. 1999; 4965-70; Proceedings of the National Academy of Sciences of the United States of America. PMID: 10220402 Bradford CS, Miller AE, Toumadje A, Nishiyama K, Shirahata S, Barnes DW, Characterization of cell cultures derived from Fugu, the Japanese pufferfish. 1997; 279-88; Molecular marine biology and biotechnology. PMID: 9418286 Peterson GL, Toumadje A, Johnson WC, Schimerlik MI, Purification of recombinant porcine m2 muscarinic acetylcholine receptor from Chinese hamster ovary cells. Circular dichroism spectra and ligand binding properties. 1995; 17808-14; The Journal of biological chemistry. PMID: 7629081 Hirschberg BT, Mosser VA, Peterson GL, Toumadje A, Vogel WK, Johnson WC, Schimerlik MI, Kinetic and biophysical analysis of the m2 muscarinic receptor. 1995; 907-13; Life sciences. PMID: 10188792 Toumadje A, Johnson WC, A CD study of the alpha-helix nucleation hypothesis. 1994; 969-73; Biopolymers. PMID: 8054475 Toumadje A, Johnson WC, Effects of relative band intensity on prediction of protein secondary structure from CD. 1993; 258-60; Analytical biochemistry. PMID: 8317701 Toumadje A, Alcorn SW, Johnson WC, Extending CD spectra of proteins to 168 nm improves the analysis for secondary structures. 1992; 321-31; Analytical biochemistry. PMID: 1632496 Riazance-Lawrence JH, Toumadje A, Johnson WC, The circular dichroism of tumor necrosis factor-alpha: measurement into the vacuum UV and analysis for secondary structure. 1991; 254-6; Chirality. PMID: 1742163 Kem WR, Tu CK, Williams RW, Toumadje A, Johnson WC, Circular dichroism and laser Raman spectroscopic analysis of the secondary structure of Cerebratulus lacteus toxin B-IV. 1990; 433-43; Journal of protein chemistry. PMID: 2275754 Miller KI, van Holde KE, Toumadje A, Johnson WC, Lamy J, Structure and function of the carboxyl-terminal oxygen-binding domain from the subunit of Octopus dofleini hemocyanin. 1988; 7282-8; Biochemistry. PMID: 3207676 Eckhardt AE, Timpte CS, Abernethy JL, Toumadje A, Johnson WC, Hill RL, Structural properties of porcine submaxillary gland apomucin. 1987; 11339-44; The Journal of biological chemistry. PMID: 3611111 Ausio J, Toumadje A, McParland R, Becker RR, Johnson WC, van Holde KE, Structural characterization of the trypsin-resistant core in the nuclear sperm-specific protein from Spisula solidissima. 1987; 975-82; Biochemistry. PMID: 3567164 Hurle MR, Matthews CR, Cohen FE, Kuntz ID, Toumadje A, Johnson WC, Prediction of the tertiary structure of the alpha-subunit of tryptophan synthase. 1987; 210-24; Proteins. PMID: 3328862