Currently, our faculty are working a number of projects in General Thoracic Surgery and Lung Transplantation. Click on a program below to learn more about their specific research projects:
The TCV Lab had its origins over 35 years ago in the early 1980’s here at the University of Virginia and continues to flourish and be productive up to the present time. As evidence of this productivity, Dr. Kron has been an author or co-author of more papers published in The Annals of Thoracic Surgery than any other author in that journal’s history. The vast majority of these papers were co-authored by residents who spent time in the TCV lab. The lab group continues to welcome interest from UVA students and surgery residents, as well as from residents other training programs who can be supported with the T32 training grant.
The main focus of this program is on understanding the molecular and cellular mechanisms of lung injury relevant to lung transplantation and particularly to chronic allograft rejection. Another focus is on improving the quality of marginal lungs though a novel technique, called Ex-Vivo Lung Perfusion (EVLP). Lung transplantation currently is the preferred treatment option for a variety of end-stage pulmonary diseases.
The Health Services and Outcomes Research in Thoracic Surgery program is dedicated to improving the quality of care for thoracic surgery patients. The program is led by Benjamin D. Kozower, MD, MPH who is a general thoracic surgeon and completed his Master of Public Health degree at the University of Virginia. Health services research examines health care quality and effectiveness, patient outcomes, access to care, health care costs and financing, new technologies, and other critical topics.
Proposed New Research Program in Lung Transplantation | Dr. Mark Roeser
Dr. Roeser has applied to the TSFRE for funding for a project which proposes to study the role of rapamycin in treatment of bronchiolitis obliterans syndrome (BOS) in pediatric lung transplantation using a small animal model. The proposed small animal model of BOS will emulate one that was developed at the University of Iowa and will take advantage of the considerable experience of The TCV Lab in transplantation in immature animals. The intent is to use CT scans to track the development of BOS, which is the approach used clinically to follow pediatric lung transplant patients. Briefly, a left lower lobe transplant will be performed in an immature animal. After these transplants CT scans will be used to measure BOS and track fibrocyte levels and to evaluate the effectiveness of rapamycin in ameliorating BOS. The hypothesis to be studied is that the rapamycin will decrease the fibrocyte levels and attenuate BOS in these animals.