Current Programs in Congenital Cardiac Surgery

Behavioral Deficits of Cardiopulmonary Bypass

An overwhelming majority of our patients undergoing repair of congenital heart defects require cardiopulmonary bypass (CPB). Many of these patients are complex neonatal repairs involving deep hypothermic circulatory arrest (DHCA) and/or periods of regional cerebral perfusion (RCP). However, concerns about the effects of this type of surgery on the brain continue to grow, and long-term cognitive deficits have been reported. The availability of replicable outcome measures for long-term behavioral deficits in an experimental model of CPB would be useful in assisting the search for mechanisms of, and treatments for CPB, DHACA, and RCP-related injury. We are in the process of collaborating with Department of Neuroscience to examine whether persistent behavioral deficits occur using our established rodent model of CPB.

Clinical Research in Congenital Cardiac Surgery

We are an active member of the STS Congenital Database. We have several ongoing, IRB approved clinical trials. We are currently looking at our clinical experience of the Hybrid Procedure vs. Norwood Palliation for high-risk hypoplastic right heart syndrome patients. We are also looking at optimal first stage palliation techniques by prospectively looking at right vs. left sided right ventricular to pulmonary artery conduits for complex single ventricle physiology. We have also developed and are studying specific protocols in an attempt to determine a best practice for pediatric postoperative sternal incision care.

Lab Members

GangemiJJames J. Gangemi, MD
Assistant Professor of Surgery and Pediatrics
Division of Thoracic and Cardiovascular Surgery

 
 
 
 
 

RoeserMMark Roeser, MD
Assistant Professor of Surgery and Pediatrics
Division of Thoracic and Cardiovascular Surgery

 
 
 
 
 

Contact

James J. Gangemi, MD
Assistant Professor of Surgery and Pediatrics
PO Box 800679
University of Virginia
Charlottesville, VA 22908

Phone: 434-243-6828
Fax: 434-244-7588
Email: jgangemi@virginia.edu