Basic Science Publications
(Research trainees are underlined)
Strobel RJ, Ta HQ, Young AM, Wisniewski AM, Norman AV, Rotar EP, Stoler MH, Kron IL, Sonkusare SK, Roeser ME, Laubach VE. TRPV4 channel inhibition attenuates lung ischemia-reperfusion injury in a porcine lung transplant model. J Thorac Cardiovasc Surg In Press (Accepted Mar 4, 2024).
Kuppusamy M, Ta HQ, Davenport HN, Bazaz A, Kulshrestha A, Daneva Z, Chen YL, Carrott PW, Laubach VE, Sonkusare SK. Purinergic P2Y2 receptor-induced activation of endothelial TRPV4 channels mediates lung ischemia-reperfusion injury. Sci Signal. 16(808):eadg1553, 2023. [Link]
Ta HQ, Teman NR, Kron IL, Roeser ME, Laubach VE. Steen solution protects pulmonary microvascular endothelial cells and preserves endothelial barrier after lipopolysaccharide-induced injury. J Thorac Cardiovasc Surg 165(1):e5-20, 2023. [Link]
Rotar EP, Haywood NS, Mehaffey JH, Money DT, Ta HQ, Stoler MH, Teman NR, Laubach VE, Kron IL, Roeser ME. Gastric aspiration and ventilator-induced model of acute respiratory distress syndrome in swine. J Surg Res 280:280-7, 2022. [Link]
Sonkusare SK and Laubach VE. [Invited Review] Endothelial TRPV4 channels in lung edema and injury. Curr Top Membr 89:43-62, 2022. [Link]
Haywood N, Ta HQ, Zhang A, Charles EJ, Rotar E, Noona S, Salmon M, Daneva Z, Sonkusare SK, Laubach VE. Endothelial transient receptor potential V4 channels mediate lung ischemia-reperfusion injury. Ann Thorac Surg 113(4):1256-64, 2022. [Link]
Haywood N, Byler MR, Zhang A, Rotar EP, Money D, Gradecki SE, Ta HQ, Salmon M, Kron IL, Laubach VE, Mehaffey JH, Roeser ME. Secondary burn progression mitigated by an adenosine 2A receptor agonist. J Burn Care Res 43(1):133-40, 2022. [Link]
Byler MR, Haywood NS, Money DT, Zhang A, Beller JP, Charles EJ, Chancellor WZ, Ta HQ, Stoler MH, Mehaffey JH, Laubach VE, Kron IL, Roeser ME. Two hours of in vivo lung perfusion improves lung function in sepsis-induced acute respiratory distress syndrome. Semin Thorac Cardiovasc Surg 34(1):337-46, 2022. [Link]
Haywood N, Ta HQ, Rotar E, Daneva Z, Sonkusare SK, Laubach VE. [Invited Review] Role of the purinergic signaling network in lung ischemia-reperfusion injury. Curr Opin Organ Transplant 26(2):250-7, 2021. [Link]
Isolated lung perfusion in the management of acute respiratory distress syndrome. Int J Mol Sci 21(18):6820, 2020. [Link]
Charles EJ, Chordia MD, Zhao Y, Zhang Y, Mehaffey JH, Glover DK, Dimastromatteo J, Chancellor WZ, Sharma AK, Kron IL, Pan D, Laubach VE. SPECT imaging of lung ischemia-reperfusion injury using 99mTc-cFLFLF for molecular targeting of formyl peptide receptor 1. Am J Physiol Lung Cell Mol Physiol 318(2):L304-13, 2020. [Link]
Charles EJ, Tian Y, Zhang A, Wu D, Mehaffey JH, Gigliotti JC, Klibanov AL, Kron IL, Yang Z. Pulsed ultrasound attenuates the hyperglycemic exacerbation of myocardial ischemia-reperfusion injury. J Thorac Cardiovasc Surg 161(4):e297-306, 2021. [Link]
Yeudall S, Leitinger N, Laubach VE. [Invited Review] Extracellular nucleotide signaling in solid organ transplantation. Am J Transplant 20(3):633-40, 2020. [Link]
Beller JP, Byler MR, Money DT, Chancellor WZ, Zhang A, Zhao Y, Stoler MH, Narahari AK, Shannon A, Mehaffey JH, Tribble CG, Laubach VE, Kron IL, Roeser ME. Reduced flow ex vivo lung perfusion to rehabilitate donation after cardiac death lungs. J Heart Lung Transplant 39(1):74-82, 2020. [Link]
Daneva Z, Laubach VE, Sonkusare, SK. [Invited Review] Novel regulators and targets of redox signaling in pulmonary vasculature. Curr Opin Physiol 9:87-93, 2019. [Link]
Myc LA, Shim YM, Laubach VE, Dimastromatteo J. [Invited Review] Role of medical and molecular imaging in COPD. Clin Transl Med 8(1):12, 2019. [Link]
Narahari AK, Charles EJ, Mehaffey JH, Hawkins RB, Sharma AK, Laubach VE, Tribble CG, Kron IL. Can lung transplant surgeons still be scientists? High productivity despite competitive funding. Heart Surg Forum 22(1):E1-7, 2019. [Link]
Mehaffey JH, Money D, Charles EJ, Schubert S, Pineros AF, Wu D, Bontha SV, Hawkins R, Teman NR, Laubach VE, Mas VR, Tribble CG, Maluf DG, Sharma AK, Yang, Z, Kron IL, Roeser ME. Adenosine 2A receptor activation attenuates ischemia reperfusion injury during extracorporeal cardiopulmonary resuscitation. Ann Surg 269(6):1176-83, 2019. [Link]
Charles EJ, Mehaffey JH, Huerter ME, Sharma AK, Stoler MH, Roeser ME, Walters DM, Tribble CG, Kron IL, Laubach VE. Ex vivo assessment of porcine donation after circulatory death lungs that undergo increasing warm ischemia times. Transplant Direct 4(12):e405, 2018. [Link]
Sharma AK, Charles EJ, Zhao Y, Narahari AK, Baderdinni PK, Good ME, Lorenz UM, Kron IL, Bayliss DA, Ravichandran KS, Isakson BE, Laubach VE. Pannexin 1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 315(2):L301-12, 2018. [Link]
Mehaffey JH, Charles EJ, Narahari AK, Schubert S, Laubach VE, Teman NR, Lynch KR, Kron IL, Sharma AK. Increasing circulating sphingosine-1-phosphate attenuates lung injury during ex vivo lung perfusion. J Thorac Cardiovasc Surg 156(2):910-7, 2018. [Link]
Mehaffey JH, Money D, Charles EJ, Schubert S, Pineros AF, Wu D, Bontha SV, Hawkins R, Teman NR, Laubach VE, Mas VR, Tribble CG, Maluf DG, Sharma AK, Yang, Z, Kron IL, Roeser ME. Adenosine 2A receptor activation attenuates ischemia reperfusion injury during extracorporeal cardiopulmonary resuscitation. Ann Surg 269(6):1176-83, 2019. [Link]
Dimastromatteo J, Charles EJ, Laubach VE. [Invited Review] Molecular imaging of pulmonary diseases. Respir Res 19(1):17, 2018. [Link]
Mehaffey JH, Charles EJ, Schubert S, Salmon M, Sharma AK, Money D, Stoler MH, Laubach VE, Tribble CG, Roeser ME, Kron IL. In vivo lung perfusion rehabilitates sepsis-induced lung injury. J Thorac Cardiovasc Surg 155(1):440-8, 2018. [Link]
Stone ML, Zhao Y, Smith JR, Weiss ML, Kron IL, Laubach VE, Sharma AK. Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death. Resp Res 18(1):212, 2017. [Link]
Charles EJ, Mehaffey JH, Sharma AK, Zhao Y, Stoler MH, Isbell JM, Lau CL, Tribble CB, Laubach VE, Kron IL. Lungs donated after circulatory death and prolonged warm ischemia are successfully transplanted after enhanced ex vivo lung perfusion using adenosine A2B receptor antagonism. J Thorac Cardiovasc Surg 154(5):1811-20, 2017. [Link]
Charles EJ, Huerter ME, Wagner CE, Sharma AK, Zhao Y, Stoler MH, Mehaffey JH, Isbell JM, Lau CL, Tribble CG, Laubach VE, Kron IL. Donation after circulatory death lungs transplantable up to six hours after ex vivo lung perfusion. Ann Thorac Surg 102(6):1845-53, 2016. [Link]
Mehaffey JH, Charles EJ, Sharma AK, Money DT, Zhao Y, Stoler MH, Lau CL, Tribble CG, Laubach VE, Roeser ME, Kron IL. Airway pressure release ventilation during ex vivo lung perfusion attenuates injury. J Thorac Cardiovasc Surg 153(1):197-204, 2017. [Link]
Mehaffey JH, Charles EJ, Sharma AK, Salmon M, Money DT, Schubert S, Stoler MH, Tribble CG, Laubach VE, Roeser ME, Kron IL. Ex vivo lung perfusion rehabilitates sepsis-induced lung injury. Ann Thorac Surg 103:1723-9, 2017. [Link]
Huerter ME, Sharma AK, Zhao Y, Charles EJ, Kron IL, Laubach VE. Attenuation of pulmonary ischemia-reperfusion injury by adenosine A2B receptor antagonism. Ann Thorac Surg 102(2):385-93, 2016. [Link]
Laubach VE and Sharma, AK. [Invited Review] Mechanisms of Lung Ischemia-Reperfusion Injury. Curr Opin Organ Transplant 21(3):246-52, 2016. [Link]
Sharma AK, LaPar DJ, Stone ML, Zhao Y, Mehta CK, Kron IL, Laubach VE. NOX2 activation of NKT cells is blocked by adenosine A2A receptor to inhibit lung reperfusion injury. Am J Respir Crit Care Med 193(9):988-99, 2016. [Link]
Zhao Y, Gillen JR, Meher AK, Burns JA, Kron IL, Lau CL. Rapamycin prevents bronchiolitis obliterans through increasing infiltration of regulatory B cells in a murine tracheal transplantation model. J Thorac Cardiovasc Surg 151(2):487-496.e3, 2016. [Link]
Wagner, CE, Pope NH, Charles EJ, Huerter ME, Sharma AK, Salmon MD, Carter T, Stoler MH, Lau CL, Laubach VE, Kron IL. Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of donation after cardiac death donor lungs. J Thorac Cardiovasc Surg 151(2):538-46, 2016. [Link]
Stone ML, Sharma AK, Mas VR, Gehrau RC, Mulloy DP, Zhao Y, Lau CL, Kron IL, Laubach VE. Ex vivo perfusion with adenosine A2A receptor agonist enhances rehabilitation of murine donor lungs after circulatory death. Transplantation 99(12):2494-503, 2015. [Link]
Stone ML, Sharma AK, Zhao Y, Charles EJ, Johnston WF, Kron IL, Lynch KR, Laubach VE. Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 308:L1245-52, 2015. [Link]
Sharma AK, Mulloy DP, Le LT, Laubach VE. NADPH oxidase mediates synergistic effects of IL-17 and TNF-α on CXCL1 expression by epithelial cells after lung ischemia-reperfusion. Am J Physiol Lung Cell Mol Physiol 306:L69-79, 2014. [Link]
Zhao Y, Gillen JR, Harris DA, Kron IL, Murphy MP, Lau CL.Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model. J Thorac Cardiovasc Surg 147(5):1668-77, 2014. [Link]
Mulloy DP, Sharma AK, Fernandez LG, Zhao Y, Lau CL, Kron IL, Laubach VE. Adenosine A3 receptor activation attenuates lung ischemia-reperfusion injury. Ann Thorac Surg 95:1762-7, 2013. [Link]
Sharma AK, LaPar DJ, Stone ML, Zhao Y, Kron IL, Laubach VE. Receptor for advanced glycation end products (RAGE) on iNKT cells mediates lung ischemia-reperfusion injury. Amer J Transplant 13:2255-67, 2013. [Link]
Gillen JR, Zhao Y, Harris DA, Lapar DJ, Stone ML, Fernandez LG, Kron IL, Lau CL. Rapamycin blocks fibrocyte migration and attenuates bronchiolitis obliterans in a murine model. Ann Thorac Surg 95(5):1768-75, 2013. [Link]
Fernandez LG, Sharma AK, LaPar DJ, Kron IL, Laubach VE. Adenosine A1 receptor activation attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 145:1654-9, 2013. [Link]
Mulloy DP, Stone ML, Crosby IK, LaPar DJ, Sharma AK, Webb DV, Lau CL, Laubach VE, Kron IL. Ex vivo rehabilitation of non-heart-beating donor lungs in a preclinical porcine model: delayed perfusion results in superior lung function. J Thorac Cardiovasc Surg 144:1208-16, 2012. [Link]
Lapar DJ, Sharma AK, Hajzus VA, Zhao Y, Lau CL, French BA, Kron IL, Laubach VE. Acute hyperglycemic exacerbation of lung ischemia-reperfusion injury is mediated by receptor for advanced glycation end-products signaling. Am J Respir Cell Mol Biol 46(3):299-305, 2011. [Link]
Emaminia A, LaPar DJ, Zhao Y, Steidle JF, Harris DA, Laubach VE, Linden J, Kron IL, Lau CL. Adenosine A(2A) agonist improves lung function during ex-vivo lung perfusion. Ann Thorac Surg 92:1840-6, 2011. [Link]
LaPar DJ, Laubach VE, Emaminia A, Crosby IK, Sharma AK, Sumner HM, Webb DV, Lau CL, and Kron IL. Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model. J Thorac Cardiovasc Surg 142(4):887-94, 2011. [Link]
Sharma AK, LaPar DJ, Zhao Y, Li L, Lau CL, Kron IL, Iwakura Y, Okusa MD, and Laubach VE. Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury. Am J Respir Crit Care Med 183(11):1539-49, 2011. [Link]
Zhao Y, Sharma AK, LaPar DJ, Kron IL, Liu Y, Jones D, Laubach VE, and Lau CL. Depletion of tissue plasminogen activator attenuates lung ischemia-reperfusion injury via inhibition of neutrophil extravasation. Am J Physiol Lung Cell Mol Physiol 300(5):L718-29, 2011. [Link]
Laubach VE, French BA, Okusa MD. Targeting of adenosine receptors in ischemia-reperfusion injury. Expert Opin Ther Targets 15(1):103-18, 2011. [Link]
Anvari F, Sharma AK, Fernandez LG, Hranjec T, Ravid K, Kron IL and Laubach VE. Tissue-derived pro-inflammatory effect of adenosine A2B receptor in lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 140:871-7, 2010. [Link]
Gazoni LM, Walters DM, Unger EB, Linden J, Kron IL, and Laubach VE. Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 140(2):440-6, 2010. [Link]
Sharma AK, Laubach VE, Ramos SI, Zhao Y, Linden J, Kron IL, and Yang Z. Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 139(2):474-82, 2010. [Link]
Laubach VE and Kron IL. Pulmonary inflammation after lung transplantation. [Review] Surgery 146(1):1-4, 2009. [Link]
Lau CL, Zhao Y, Kron IL, Stoler MH, Laubach VE, Ailawadi G, and Linden J. The Role of Adenosine A2A Receptor Signaling in Bronchiolitis Obliterans. Ann Thorac Surg 88(4):1071-8, 2009. [Link]
Sharma AK, Linden J, Kron IL, and Laubach VE. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Respiratory Research 10:58, 2009. [Link]
Lau CL, Zhao Y, Kim J, Kron IL, Sharma A, Yang Z, Laubach VE, Linden J, Ailawadi G, and Pinsky DJ. Enhanced fibrinolysis protects against lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 137(5):1241-8, 2009. [Link]
Yang Z, Sharma AK, Linden J, Kron IL, and Laubach VE. CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury. J Thorac Cardiovasc Surg 137(3):695-702, 2009. [Link]
Yang Z, Laubach VE, French BA, and Kron IL. Acute hyperglycemia enhances oxidative stress and exacerbates myocardial infarction by activating NADPH oxidase during reperfusion. J Thorac Cardiovasc Surg 137(3):723-9, 2009. [Link]
Yang Z, Sharma AK, Marshall M, Kron IL, and Laubach VE. NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury. Am J Resp Cell Mol Biol 40(3):375-81, 2009. [Link]
Lisle TC, Fernandez LG, Sharma AK, Bellizzi AM, Gazoni LM, Linden J, Laubach VE, and Kron IL. Inflammatory lung injury after cardiopulmonary bypass is attenuated by adenosine A(2A) receptor activation. J Thorac Cardiovasc Surg 136(5):1280-7, 2008. [Link]
Ellman PI, Reece TB, Gazoni LM, Singh R, Laubach VE, Tribble CG, and Kron IL. Adenosine A2A activation attenuates non-tranplantation lung reperfusion injury. J Surg Res 149:3-8, 2008. [Link]
Gazoni LM, Laubach VE, Mulloy DP, Bellizzi A, Unger EB, Linden J, Ellman PI, Lisle TC, Kron IL. Additive protection against lung ischemia-reperfusion injury by adenosine A2A receptor activation before procurement and during reperfusion. J Thorac Cardiovasc Surg 135(1):156-65, 2008. [Link]
Fernandez LG, Mehta CK, Kron IL, and Laubach VE. Re-initiation of compensatory lung growth after subsequent lung resection. J Thorac Cardiovasc Surg 134:1300-5, 2007. [Link]
Sharma AK, Fernandez LG, Awad AS, Kron IL, and Laubach VE. Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 293:105-13, 2007. [Link]
Gazoni LM, Tribble CG, Zhao MQ, Unger EB, Farrar RA, Ellman PI, Fernandez LG, Laubach VE, and Kron IL. Pulmonary macrophage inhibition and inhaled nitric oxide attenuate lung ischemia reperfusion injury. Ann Thorac Surg 84:247-53, 2007. [Link]
Fernandez LG, Le Cras TD, Ruiz M, Glover DK, Kron IL, and Laubach VE. Differential vascular growth in postpneumonectomy compensatory lung growth. J Thorac Cardiovasc Surg 133:309-16, 2007. [Link]
Zhao M, Fernandez LG, Doctor A, Sharma AK, Zarbock A, Tribble CG, Kron IL, and Laubach VE. Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 291:L1018-26, 2006. [Link]
Singh RR, Laubach VE, Ellman PI, Reece TB, Unger E, Kron IL, and Tribble CG. Attenuation of lung reperfusion injury by modified ventilation and reperfusion techniques. J Heart Lung Transplant 25:1467-73, 2006. [Link]
Maxey TS, Fernandez LG, Reece TB, Keeling WB, Kron IL, and Laubach VE. Endothelial nitric oxide synthase is essential for postpneumonectomy compensatory vasodilation. Ann Thorac Surg 81:1234-8, 2006. [Link]
Reece TB, Ellman PI, Maxey TS, Crosby IK, Warren PS, Chong TW, LeGallo RD, Linden J, Kern JA, Tribble CG, and Kron IL. Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantation. J Thorac Cardiovasc Surg 129:1137-43, 2005. [Link]
Patel MR, Laubach VE, Tribble CG, and Kron IL. Hyperinflation during lung preservation and increased reperfusion injury. J Surg Res 123:134-8, 2005. [Link]
Li D, Fernandez LG, Dodd-o J, Langer J, Wang D, and Laubach VE. Upregulation of hypoxia-induced mitogenic factor in compensatory lung growth after pneumonectomy. Am J Respir Cell Mol Biol 32:185-91, 2005. [Link]
Le Cras TD, Fernandez LG, Pastura PA, and Laubach VE. Vascular growth and remodeling in compensatory lung growth following right lobectomy. J Appl Physiol 98:1140-8, 2005. [Link]
Maxey TS, Enelow RI, Gaston B, Kron IL, Laubach VE, and Doctor A. Tumor necrosis factor-alpha from resident lung cells is a key initiating factor in pulmonary ischemia-reperfusion injury. J Thorac Cardiovasc Surg 127:541-7, 2004. [Link]