Victor E. Laubach, PhD
Professor of Surgery (with tenure)
Professor of Molecular Physiology and Biological Physics
PhD 1993, Genetics, The George Washington University
I obtained a B.S. in Biology from Penn State University and then a Ph.D. in Genetics from the George Washington University. I conducted my graduate research in the laboratory of Dr. Mark Brantly at NIH/NHLBI where I studied alpha-1-antitrypsin deficiency. I then did 3 years of postdoctoral research at Glaxo Wellcome Pharmaceuticals in Research Triangle Park, NC to study nitric oxide biology. Here, I generated the iNOS knockout mouse and helped generate the eNOS knockout mouse in collaboration with the late Dr. Oliver Smithies, who received the Nobel Prize in 2007 for his genetic knockout methodology. In 1996 I came to the UVA Department of Surgery as an Assistant Professor where I began my studies on lung transplantation, which continue today.
My laboratory conducts basic and translational studies into the pathogenesis of lung ischemia-reperfusion injury (IRI) after transplantation. IRI is characterized by robust inflammation, leukocyte infiltration, alveolar damage, and vascular permeability in the lung acutely after transplantation, which leads to primary graft dysfunction (PGD). IRI is also a risk factor for chronic lung allograft dysfunction; the major cause of mortality beyond one year of transplantation. The overarching objectives of my lab are three-fold: 1) to define mechanisms of IRI, 2) to discover therapeutic strategies to prevent IRI, and 3) to develop molecular imaging methods for early detection of IRI. The comprehensive approach of our research integrates rodent, large animal, and in vitro models to study lung IRI at multiple levels, and our research program is driven by its ultimate goal of improving patient outcomes after lung transplantation.
Links to learn more about Dr. Laubach:
Department of Surgery
University of Virginia
P.O. Box 801359
Bldg MR4, Rm 3112
409 Lane Road
Charlottesville, VA 22908