Victor E. Laubach, PhD

Victor E. Laubach, PhD

Professor of Surgery
Professor of Molecular Physiology and Biological Physics
PhD 1993, Genetics, The George Washington University

Biography:

I grew up in central Pennsylvania where I always had a strong curiosity about science and biology. After graduating from Penn State University (University Park, PA) with a B.S. in Biology, I went on to graduate school at the George Washington University (Washington D.C.) for my PhD in Genetics. I conducted my graduate research in the laboratory of Dr. Mark Brantly in the Human Genetics Branch of  NICHD/NIH in Bethesda, MD. My graduate research focused on characterizing novel genotypes of the alpha-1-antitrypsin gene and how these mutations resulted in a null phenotype. I went on to do 3 years of postdoctoral research at Glaxo Wellcome pharmaceutical (now GlaxoSmithKline) where my work focused on nitric oxide research. Here I generated the iNOS knockout mouse and contributed to the development of the eNOS knockout mouse in collaboration with the late Dr. Oliver Smithies, who received the Nobel Prize in Physiology or Medicine in 2007 for his  genetic knockout methodology. In 1996 I then went to the University of Virginia’s Department of Surgery as an Assistant Professor where I began my studies on lung transplantation, which continue today.

Research Interests:

My laboratory conducts translational studies into mechanisms and prevention of lung ischemia-reperfusion (IR) injury following transplantation. IR injury, due to a rapid and robust inflammatory response, is the main cause of primary graft dysfunction and remains a significant and perplexing cause of morbidity and mortality after lung transplant. IR injury also leads to an increased risk for chronic graft dysfunction and rejection. Our research utilizes both in vivo and in vitro models to explore inflammatory signaling pathways in innate immune cells, epithelial cells and endothelial cells as well as cross-talk among these cell types and discovering novel therapeutic targets and strategies to prevent or treat IR injury.

Links to learn more about Dr. Laubach:

* UVA Research Faculty Directory
* Cardiovascular Research Center
* LinkedIn profile
* CTSNet profile
* NIH Biosketch
* PubMed listing for Victor E. Laubach

Contact Information:

Department of Surgery
University of Virginia
P.O. Box 801359
Bldg MR4, Rm 3112
409 Lane Road
Charlottesville, VA 22908
Office: 434-924-2927
Fax: 434-924-1218
Email: laubach@virginia.edu