Reduction of Femoral Artery Bleeding Post Catheterization Using a Collagen Enhanced Fibrin Sealant
Jeanne K. Falstrom, MA, Norman C. Goodman, BS, Gursel Ates, MD,
Robert D. Abbott, PhD, Eric R. Powers, MD, and William D. Spotnitz, MD
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Catheterization and Cardiovascular Diagnosis 1997;41:79-84
As the number of cardiac catheterization procedures increases, so do associated complications and costs. This study suggests that the application of a new collagen enhanced fibrin sealant, Collaseal®, may be used effectively to achieve rapid hemostasis at the arterial puncture site following femoral artery catheterization. Results in nine dogs anticoagulated with heparin (activated clotting time 396 +/- 107, mean +/- S.D.) revealed a statistically significant reduction in signs of gross bleeding in the sealant-treated groins as compared to control (2 versus 9, P = .0156). These results indicate that this comercially produced sealant might be used in human patients undergoing cardiac catheterization to decrease complications, lengths of stay, and costs.